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The book demonstrates that these challenges are amenable to organizational and managerial solutions, and therefore health care management research has many important lessons to contribute.   For this volume, The Contributions of Health Care Management to Grand Health Care Challenges, we define health care management as the planning, direction, and coordination of health services and the management of health care professionals. Included chapters consider five grand challenges facing the health care sector: (1) caring for vulnerable populations; (2) maintaining the health care workforce; (3) translating innovation into practice; (4) sustaining organizations; and (5) navigating pandemics. Each challenge is discussed in its own section and addressed by two chapters that offer different perspectives and approaches to the challenge. 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Leaders in healthcare require a comprehensive understanding of effective approaches to organizational change, yet the theoretical and practical landscape is evolving rapidly.   Volume 22 of Advances in Health Care Management focuses on environmental uncertainty and the responsiveness of health care organizations, the mechanisms of change and how leaders within organizations frame and execute change, and investigates organizational preparedness and response in the face of acute crisis. 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